PUBLICATIONS
Reconstitution of Microtubule into GTP-Responsive Nanocapsules
Noriyuki Uchida, Ai Kohata, Kou Okuro, Annalisa Cardellini, Chiara Lionello, Eric A. Zizzi, Marco A. Deriu, Giovanni M. Pavan, Michio Tomishige, Takaaki Hikima, Takuzo Aida*
Nat. Commun. 2022, 13, 5424. DOI: 10.1038/s41467-022-33156-5
Noriyuki Uchida, Ai Kohata, Kou Okuro, Annalisa Cardellini, Chiara Lionello, Eric A. Zizzi, Marco A. Deriu, Giovanni M. Pavan, Michio Tomishige, Takaaki Hikima, Takuzo Aida*
Nat. Commun. 2022, 13, 5424. DOI: 10.1038/s41467-022-33156-5
Photoreactive Molecular Glue for Enhancing the Efficacy of DNA Aptamers by Temporary-to-Permanent Conjugation with Target Proteins
Ai Kohata, Ryosuke Ueki, Kou Okuro,* P. K. Hashim, Shinsuke Sando, Takuzo Aida*
J. Am. Chem. Soc. 2021, 143, 13937–13943. DOI: 10.1021/jacs.1c06816
Highlighted by JACS Spotlights
Ai Kohata, Ryosuke Ueki, Kou Okuro,* P. K. Hashim, Shinsuke Sando, Takuzo Aida*
J. Am. Chem. Soc. 2021, 143, 13937–13943. DOI: 10.1021/jacs.1c06816
Highlighted by JACS Spotlights
Bio-Adhesive Nanoporous Module: Toward Autonomous Gating
Hyuna Jo, Takashi Kitao, Ayumi Kimura, Yoshimitsu Itoh, Takuzo Aida,* Kou Okuro*
Angew. Chem., Int. Ed. 2021, 60, 8932–8937. DOI: 10.1002/anie.202017117
Selected as "Hot Paper", Highlighted by Front Cover and ChemistryViews
Hyuna Jo, Takashi Kitao, Ayumi Kimura, Yoshimitsu Itoh, Takuzo Aida,* Kou Okuro*
Angew. Chem., Int. Ed. 2021, 60, 8932–8937. DOI: 10.1002/anie.202017117
Selected as "Hot Paper", Highlighted by Front Cover and ChemistryViews
Intracellular Photoactivation of Caspase-3 by Molecular Glues for Spatiotemporal Apoptosis Induction
Nina B. Hentzen, Rina Mogaki, Saya Otake, Kou Okuro,* Takuzo Aida*
J. Am. Chem. Soc. 2020, 142, 8080–8084. DOI: 10.1021/jacs.0c01823
Highlighted by Cover
Nina B. Hentzen, Rina Mogaki, Saya Otake, Kou Okuro,* Takuzo Aida*
J. Am. Chem. Soc. 2020, 142, 8080–8084. DOI: 10.1021/jacs.0c01823
Highlighted by Cover
Asymmetric Catalysis Mediated by a Mirror Symmetry-Broken Helical Nanoribbon
Zhaocun Shen,* Yutao Sang, Tianyu Wang, Jian Jiang, Yan Meng, Yuqian Jiang, Kou Okuro,* Takuzo Aida,* Minghua Liu*
Nat. Commun. 2019, 10, 3976. DOI: 10.1038/s41467-019-11840-3
Zhaocun Shen,* Yutao Sang, Tianyu Wang, Jian Jiang, Yan Meng, Yuqian Jiang, Kou Okuro,* Takuzo Aida,* Minghua Liu*
Nat. Commun. 2019, 10, 3976. DOI: 10.1038/s41467-019-11840-3
Molecular Glue that Spatiotemporally Turns on Protein–Protein Interactions
Rina Mogaki, Kou Okuro,* Ryosuke Ueki, Shinsuke Sando, Takuzo Aida*
J. Am. Chem. Soc. 2019, 141, 8035–8040. DOI: 10.1021/jacs.9b02427
Highlighted by JACS Spotlights and Cover
Rina Mogaki, Kou Okuro,* Ryosuke Ueki, Shinsuke Sando, Takuzo Aida*
J. Am. Chem. Soc. 2019, 141, 8035–8040. DOI: 10.1021/jacs.9b02427
Highlighted by JACS Spotlights and Cover
Transferrin-Appended Nanocaplet for Transcellular siRNA Delivery into Deep Tissues
Ai Kohata, P. K. Hashim, Kou Okuro,* Takuzo Aida*
J. Am. Chem. Soc. 2019, 141, 2862–2866. DOI: 10.1021/jacs.8b1250
Highlighted by JACS Spotlights and Cover
Ai Kohata, P. K. Hashim, Kou Okuro,* Takuzo Aida*
J. Am. Chem. Soc. 2019, 141, 2862–2866. DOI: 10.1021/jacs.8b1250
Highlighted by JACS Spotlights and Cover
Spatiotemporally Controlled Nuclear Translocation of Guests in Living Cells Using Caged Molecular Glues as Photoactivatable Tags
Rina Mogaki, Kou Okuro,* Akio Arisaka, Takuzo Aida*
J. Vis. Exp. 2019, 143, e58631. DOI: 10.3791/5863
Rina Mogaki, Kou Okuro,* Akio Arisaka, Takuzo Aida*
J. Vis. Exp. 2019, 143, e58631. DOI: 10.3791/5863
Dendritic Molecular Glues with Reductively Cleavable Guanidinium Ion Pendants: Highly Efficient Intracellular siRNA Delivery via Direct Translocation
Kou Okuro,* Harei Nemoto, Rina Mogaki, Takuzo Aida*
Chem. Lett. 2018, 47, 1232–1235. DOI: 10.1246/cl.180551
Selected as Editor's Choice, Highlighted by Cover
Kou Okuro,* Harei Nemoto, Rina Mogaki, Takuzo Aida*
Chem. Lett. 2018, 47, 1232–1235. DOI: 10.1246/cl.180551
Selected as Editor's Choice, Highlighted by Cover
Nitrobenzoxadiazole-Appended Cell Membrane Modifiers for Efficient Optoporation with Noncoherent Light
Saya Otake, Kou Okuro,* Davide Bochicchio, Giovanni M. Pavan, Takuzo Aida*
Bioconjugate Chem. 2018, 29, 2068–2073. DOI: 10.1021/acs.bioconjchem.8b0027
Saya Otake, Kou Okuro,* Davide Bochicchio, Giovanni M. Pavan, Takuzo Aida*
Bioconjugate Chem. 2018, 29, 2068–2073. DOI: 10.1021/acs.bioconjchem.8b0027
Caged Molecular Glues as Photoactivatable Tags for Nuclear Translocation of Guests in Living Cells
Akio Arisaka, Rina Mogaki, Kou Okuro,* Takuzo Aida*
J. Am. Chem. Soc. 2018, 140, 2687–2692. DOI: 10.1021/jacs.7b1361
Akio Arisaka, Rina Mogaki, Kou Okuro,* Takuzo Aida*
J. Am. Chem. Soc. 2018, 140, 2687–2692. DOI: 10.1021/jacs.7b1361
Mechanically Robust, Readily Repairable Polymers via Tailored Noncovalent Cross-linking
Yu Yanagisawa, Yiling Nan, Kou Okuro, Takuzo Aida*
Science 2018, 359, 72–76. DOI: 10.1126/science.aam758
Highlighted by Nature Review Materials
Yu Yanagisawa, Yiling Nan, Kou Okuro, Takuzo Aida*
Science 2018, 359, 72–76. DOI: 10.1126/science.aam758
Highlighted by Nature Review Materials
Guanidinium-based "Molecular Glues" for Modulation of Biomolecular Functions
Rina Mogaki, P. K. Hashim, Kou Okuro,* Takuzo Aida*
Chem. Soc. Rev. 2017, 46, 6480–6491. DOI: 10.1039/c7cs00647
Rina Mogaki, P. K. Hashim, Kou Okuro,* Takuzo Aida*
Chem. Soc. Rev. 2017, 46, 6480–6491. DOI: 10.1039/c7cs00647
Adhesive Photoswitch: Selective Photochemical Modulation of Enzymes under Physiological Conditions
Rina Mogaki, Kou Okuro,* Takuzo Aida*
J. Am. Chem. Soc. 2017, 139, 10072–10078. DOI: 10.1021/jacs.7b05151
Rina Mogaki, Kou Okuro,* Takuzo Aida*
J. Am. Chem. Soc. 2017, 139, 10072–10078. DOI: 10.1021/jacs.7b05151
Boronic Acid–Appended Molecular Glues for ATP-Responsive Activity Modulation of Enzymes
Kou Okuro,* Mizuki Sasaki, Takuzo Aida*
J. Am. Chem. Soc. 2016, 138, 5527–5530. DOI: 10.1021/jacs.6b0266
Kou Okuro,* Mizuki Sasaki, Takuzo Aida*
J. Am. Chem. Soc. 2016, 138, 5527–5530. DOI: 10.1021/jacs.6b0266
Photoinduced Bioorthogonal 1,3-Dipolar Polycycloaddition Promoted by Oxyanionic Substrates for Spatiotemporal Operation of Molecular Glues
Junichi Hatano, Kou Okuro,* Takuzo Aida*
Angew. Chem., Int. Ed. 2016, 55, 193–198. DOI: 10.1002/anie.20150798
Junichi Hatano, Kou Okuro,* Takuzo Aida*
Angew. Chem., Int. Ed. 2016, 55, 193–198. DOI: 10.1002/anie.20150798
Reductively Cleavable Nanocaplets for siRNA Delivery by Template-Assisted Oxidative Polymerization
P. K. Hashim, Kou Okuro,* Shigekazu Sasaki, Yasutaka Hoashi, Takuzo Aida*
J. Am. Chem. Soc. 2015, 137, 15608–15611. DOI: 10.1021/jacs.5b0894
P. K. Hashim, Kou Okuro,* Shigekazu Sasaki, Yasutaka Hoashi, Takuzo Aida*
J. Am. Chem. Soc. 2015, 137, 15608–15611. DOI: 10.1021/jacs.5b0894
Molecular Glues for Manipulating Enzymes: Trypsin Inhibition by Benzamidine-conjugated Molecular Glues
Rina Mogaki, Kou Okuro,* Takuzo Aida*
Chem. Sci. 2015, 6, 2802–2805. DOI: 10.1039/C5SC00524
Rina Mogaki, Kou Okuro,* Takuzo Aida*
Chem. Sci. 2015, 6, 2802–2805. DOI: 10.1039/C5SC00524
Subnanoscale Hydrophobic Modulation of Salt Bridges in Aqueous Media
Shuo Chen, Yoshimitsu Itoh,* Takuya Masuda, Seishi Shimizu, Jun Zhao, Jing Ma, Shugo Nakamura, Kou Okuro, Hidenori Noguchi, Kouhei Uosaki, Takuzo Aida*
Science 2015, 348, 555–559. DOI: 10.1126/science.aaa2421
Shuo Chen, Yoshimitsu Itoh,* Takuya Masuda, Seishi Shimizu, Jun Zhao, Jing Ma, Shugo Nakamura, Kou Okuro, Hidenori Noguchi, Kouhei Uosaki, Takuzo Aida*
Science 2015, 348, 555–559. DOI: 10.1126/science.aaa2421
Structure and Shape Effects of Molecular Glue on Supramolecular Tubulin Assemblies
Matteo Garzoni, Kou Okuro, Noriyuki Ishii, Takuzo Aida, Giovanni M. Pavan*
ACS Nano 2014, 8, 904–914. DOI: 10.1021/nn405653
Matteo Garzoni, Kou Okuro, Noriyuki Ishii, Takuzo Aida, Giovanni M. Pavan*
ACS Nano 2014, 8, 904–914. DOI: 10.1021/nn405653
Photoclickable Dendritic Molecular Glue: Noncovalent-to-Covalent Photochemical Transformation of Protein Hybrids
Noriyuki Uchida, Kou Okuro,* Yamato Niitani, Xiao Ling, Takayuki Ariga, Michio Tomishige,* Takuzo Aida*
J. Am. Chem. Soc. 2013, 135, 4684–4687. DOI: 10.1021/ja401059
Noriyuki Uchida, Kou Okuro,* Yamato Niitani, Xiao Ling, Takayuki Ariga, Michio Tomishige,* Takuzo Aida*
J. Am. Chem. Soc. 2013, 135, 4684–4687. DOI: 10.1021/ja401059
Friction-Mediated Dynamic Disordering of Phospholipid Membrane by Mechanical Motions of Photoresponsive Molecular Glue: Activation of Ion Permeation
Yushi Suzuki, Kou Okuro,* Tadashi Takeuchi, Takuzo Aida*
J. Am. Chem. Soc. 2012, 134, 15273–15276. DOI: 10.1021/ja307442
Highlighted by C&EN
Yushi Suzuki, Kou Okuro,* Tadashi Takeuchi, Takuzo Aida*
J. Am. Chem. Soc. 2012, 134, 15273–15276. DOI: 10.1021/ja307442
Highlighted by C&EN
Adhesion Effects of a Guanidinium Ion Appended Dendritic “Molecular Glue” on the ATP-driven Sliding Motion of Actomyosin
Kou Okuro, Kazushi Kinbara,* Kuniaki Takeda, Yuichi Inoue, Akihiko Ishijima, Takuzo Aida*
Angew. Chem., Int. Ed. 2010, 49, 3030–3033. DOI: 10.1002/anie.200906139
Selected as "Hot Paper", Highlighted by Nature Chemistry
Kou Okuro, Kazushi Kinbara,* Kuniaki Takeda, Yuichi Inoue, Akihiko Ishijima, Takuzo Aida*
Angew. Chem., Int. Ed. 2010, 49, 3030–3033. DOI: 10.1002/anie.200906139
Selected as "Hot Paper", Highlighted by Nature Chemistry
High-water-content Mouldable Hydrogels by Mixing Clay and a Dendritic Molecular Binder
Qigang Wang, Justin L. Mynar,* Masaru Yoshida, Eunji Lee, Myongsoo Lee, Kou Okuro, Kazushi Kinbara, Takuzo Aida*
Nature 2010, 463, 339–343. DOI: 10.1038/nature08693
Highlighted by C&EN, New Scientists, and Nature Protocols
Qigang Wang, Justin L. Mynar,* Masaru Yoshida, Eunji Lee, Myongsoo Lee, Kou Okuro, Kazushi Kinbara, Takuzo Aida*
Nature 2010, 463, 339–343. DOI: 10.1038/nature08693
Highlighted by C&EN, New Scientists, and Nature Protocols
Image Analysis of 𝛼/𝛽-Tubulin Rings in Two-dimensional Crystalline Arrays of Periodic Mesoporous Nanostructures
Noriyuki Ishii,* Kou Okuro, Kazushi Kinbara, Takuzo Aida
J. Biochem. 2010, 147, 555–563. DOI: 10.1093/jb/mvp201
Noriyuki Ishii,* Kou Okuro, Kazushi Kinbara, Takuzo Aida
J. Biochem. 2010, 147, 555–563. DOI: 10.1093/jb/mvp201
Molecular Glues Carrying Multiple Guanidinium Ion Pendants via an Oligoether Spacer: Stabilization of Microtubules against Depolymerization
Kou Okuro, Kazushi Kinbara,* Kouhei Tsumoto, Noriyuki Ishii, Takuzo Aida*
J. Am. Chem. Soc. 2009, 131, 1626–1627. DOI: 10.1021/ja800491v
Kou Okuro, Kazushi Kinbara,* Kouhei Tsumoto, Noriyuki Ishii, Takuzo Aida*
J. Am. Chem. Soc. 2009, 131, 1626–1627. DOI: 10.1021/ja800491v
Substrate Specificity and Reaction Mechanism of Recombinant Styrene Oxide Isomerase from Pseudomonas putida S12
Kenji Miyamoto, Kou Okuro, Hiromichi Ohta*
Tetrahedron Lett. 2007, 48, 3255–3257. DOI: 10.1016/j.tetlet.2007.03.016
Kenji Miyamoto, Kou Okuro, Hiromichi Ohta*
Tetrahedron Lett. 2007, 48, 3255–3257. DOI: 10.1016/j.tetlet.2007.03.016
