PUBLICATIONS
Clay Nanosheet-Based Nanocomposite Supramolecular Hydrogel Enabling Rapid, Reversible Phase Transition Only with Visible Light
Ye Fu, Jiandong Ding,* Kou Okuro,* Takuzo Aida*
Angew. Chem., Int. Ed. 2024, accepted. DOI: doi.org/10.1002/anie.202416541
Ye Fu, Jiandong Ding,* Kou Okuro,* Takuzo Aida*
Angew. Chem., Int. Ed. 2024, accepted. DOI: doi.org/10.1002/anie.202416541
Mechanotransducing Hydrogel for Switching Enzyme Reactions through Modulation of Multivalent Salt-Bridge Interactions
Yiwa Wang, Kou Okuro*
J. Am. Chem. Soc. 2024, 146, 16737–16742. DOI: 10.1021/jacs.4c04344
Yiwa Wang, Kou Okuro*
J. Am. Chem. Soc. 2024, 146, 16737–16742. DOI: 10.1021/jacs.4c04344
ATP-Responsive Nanoparticles Covered with Biomolecular Machine "Chaperonin GroEL"
Hao K. Shen, Kiyoshi Morishita, P. K. Hashim, Kou Okuro, Daiki Kashiwagi, Ayumi Kimura, Haruaki Yanagisawa, Masahide Kikkawa, Tatsuya Niwa, Hideki Taguchi, Takuzo Aida*
Angew. Chem., Int. Ed. 2023, 62, e202304894. DOI: 10.1002/anie.202304894
Hao K. Shen, Kiyoshi Morishita, P. K. Hashim, Kou Okuro, Daiki Kashiwagi, Ayumi Kimura, Haruaki Yanagisawa, Masahide Kikkawa, Tatsuya Niwa, Hideki Taguchi, Takuzo Aida*
Angew. Chem., Int. Ed. 2023, 62, e202304894. DOI: 10.1002/anie.202304894
Reconstitution of Microtubule into GTP-Responsive Nanocapsules
Noriyuki Uchida, Ai Kohata, Kou Okuro, Annalisa Cardellini, Chiara Lionello, Eric A. Zizzi, Marco A. Deriu, Giovanni M. Pavan, Michio Tomishige, Takaaki Hikima, Takuzo Aida*
Nat. Commun. 2022, 13, 5424. DOI: 10.1038/s41467-022-33156-5
Noriyuki Uchida, Ai Kohata, Kou Okuro, Annalisa Cardellini, Chiara Lionello, Eric A. Zizzi, Marco A. Deriu, Giovanni M. Pavan, Michio Tomishige, Takaaki Hikima, Takuzo Aida*
Nat. Commun. 2022, 13, 5424. DOI: 10.1038/s41467-022-33156-5
Photoreactive Molecular Glue for Enhancing the Efficacy of DNA Aptamers by Temporary-to-Permanent Conjugation with Target Proteins
Ai Kohata, Ryosuke Ueki, Kou Okuro,* P. K. Hashim, Shinsuke Sando, Takuzo Aida*
J. Am. Chem. Soc. 2021, 143, 13937–13943. DOI: 10.1021/jacs.1c06816
Highlighted by JACS Spotlights
Ai Kohata, Ryosuke Ueki, Kou Okuro,* P. K. Hashim, Shinsuke Sando, Takuzo Aida*
J. Am. Chem. Soc. 2021, 143, 13937–13943. DOI: 10.1021/jacs.1c06816
Highlighted by JACS Spotlights
Bio-Adhesive Nanoporous Module: Toward Autonomous Gating
Hyuna Jo, Takashi Kitao, Ayumi Kimura, Yoshimitsu Itoh, Takuzo Aida,* Kou Okuro*
Angew. Chem., Int. Ed. 2021, 60, 8932–8937. DOI: 10.1002/anie.202017117
Selected as "Hot Paper", Highlighted by Front Cover and ChemistryViews
Hyuna Jo, Takashi Kitao, Ayumi Kimura, Yoshimitsu Itoh, Takuzo Aida,* Kou Okuro*
Angew. Chem., Int. Ed. 2021, 60, 8932–8937. DOI: 10.1002/anie.202017117
Selected as "Hot Paper", Highlighted by Front Cover and ChemistryViews
Intracellular Photoactivation of Caspase-3 by Molecular Glues for Spatiotemporal Apoptosis Induction
Nina B. Hentzen, Rina Mogaki, Saya Otake, Kou Okuro,* Takuzo Aida*
J. Am. Chem. Soc. 2020, 142, 8080–8084. DOI: 10.1021/jacs.0c01823
Highlighted by Cover
Nina B. Hentzen, Rina Mogaki, Saya Otake, Kou Okuro,* Takuzo Aida*
J. Am. Chem. Soc. 2020, 142, 8080–8084. DOI: 10.1021/jacs.0c01823
Highlighted by Cover
Asymmetric Catalysis Mediated by a Mirror Symmetry-Broken Helical Nanoribbon
Zhaocun Shen,* Yutao Sang, Tianyu Wang, Jian Jiang, Yan Meng, Yuqian Jiang, Kou Okuro,* Takuzo Aida,* Minghua Liu*
Nat. Commun. 2019, 10, 3976. DOI: 10.1038/s41467-019-11840-3
Zhaocun Shen,* Yutao Sang, Tianyu Wang, Jian Jiang, Yan Meng, Yuqian Jiang, Kou Okuro,* Takuzo Aida,* Minghua Liu*
Nat. Commun. 2019, 10, 3976. DOI: 10.1038/s41467-019-11840-3
Molecular Glue that Spatiotemporally Turns on Protein–Protein Interactions
Rina Mogaki, Kou Okuro,* Ryosuke Ueki, Shinsuke Sando, Takuzo Aida*
J. Am. Chem. Soc. 2019, 141, 8035–8040. DOI: 10.1021/jacs.9b02427
Highlighted by JACS Spotlights and Cover
Rina Mogaki, Kou Okuro,* Ryosuke Ueki, Shinsuke Sando, Takuzo Aida*
J. Am. Chem. Soc. 2019, 141, 8035–8040. DOI: 10.1021/jacs.9b02427
Highlighted by JACS Spotlights and Cover
Transferrin-Appended Nanocaplet for Transcellular siRNA Delivery into Deep Tissues
Ai Kohata, P. K. Hashim, Kou Okuro,* Takuzo Aida*
J. Am. Chem. Soc. 2019, 141, 2862–2866. DOI: 10.1021/jacs.8b1250
Highlighted by JACS Spotlights and Cover
Ai Kohata, P. K. Hashim, Kou Okuro,* Takuzo Aida*
J. Am. Chem. Soc. 2019, 141, 2862–2866. DOI: 10.1021/jacs.8b1250
Highlighted by JACS Spotlights and Cover
Spatiotemporally Controlled Nuclear Translocation of Guests in Living Cells Using Caged Molecular Glues as Photoactivatable Tags
Rina Mogaki, Kou Okuro,* Akio Arisaka, Takuzo Aida*
J. Vis. Exp. 2019, 143, e58631. DOI: 10.3791/5863
Rina Mogaki, Kou Okuro,* Akio Arisaka, Takuzo Aida*
J. Vis. Exp. 2019, 143, e58631. DOI: 10.3791/5863
Dendritic Molecular Glues with Reductively Cleavable Guanidinium Ion Pendants: Highly Efficient Intracellular siRNA Delivery via Direct Translocation
Kou Okuro,* Harei Nemoto, Rina Mogaki, Takuzo Aida*
Chem. Lett. 2018, 47, 1232–1235. DOI: 10.1246/cl.180551
Selected as Editor's Choice, Highlighted by Cover
Kou Okuro,* Harei Nemoto, Rina Mogaki, Takuzo Aida*
Chem. Lett. 2018, 47, 1232–1235. DOI: 10.1246/cl.180551
Selected as Editor's Choice, Highlighted by Cover
Nitrobenzoxadiazole-Appended Cell Membrane Modifiers for Efficient Optoporation with Noncoherent Light
Saya Otake, Kou Okuro,* Davide Bochicchio, Giovanni M. Pavan, Takuzo Aida*
Bioconjugate Chem. 2018, 29, 2068–2073. DOI: 10.1021/acs.bioconjchem.8b0027
Saya Otake, Kou Okuro,* Davide Bochicchio, Giovanni M. Pavan, Takuzo Aida*
Bioconjugate Chem. 2018, 29, 2068–2073. DOI: 10.1021/acs.bioconjchem.8b0027
Caged Molecular Glues as Photoactivatable Tags for Nuclear Translocation of Guests in Living Cells
Akio Arisaka, Rina Mogaki, Kou Okuro,* Takuzo Aida*
J. Am. Chem. Soc. 2018, 140, 2687–2692. DOI: 10.1021/jacs.7b1361
Akio Arisaka, Rina Mogaki, Kou Okuro,* Takuzo Aida*
J. Am. Chem. Soc. 2018, 140, 2687–2692. DOI: 10.1021/jacs.7b1361
Mechanically Robust, Readily Repairable Polymers via Tailored Noncovalent Cross-linking
Yu Yanagisawa, Yiling Nan, Kou Okuro, Takuzo Aida*
Science 2018, 359, 72–76. DOI: 10.1126/science.aam758
Highlighted by Nature Review Materials
Yu Yanagisawa, Yiling Nan, Kou Okuro, Takuzo Aida*
Science 2018, 359, 72–76. DOI: 10.1126/science.aam758
Highlighted by Nature Review Materials
Guanidinium-based "Molecular Glues" for Modulation of Biomolecular Functions
Rina Mogaki, P. K. Hashim, Kou Okuro,* Takuzo Aida*
Chem. Soc. Rev. 2017, 46, 6480–6491. DOI: 10.1039/c7cs00647
Rina Mogaki, P. K. Hashim, Kou Okuro,* Takuzo Aida*
Chem. Soc. Rev. 2017, 46, 6480–6491. DOI: 10.1039/c7cs00647
Adhesive Photoswitch: Selective Photochemical Modulation of Enzymes under Physiological Conditions
Rina Mogaki, Kou Okuro,* Takuzo Aida*
J. Am. Chem. Soc. 2017, 139, 10072–10078. DOI: 10.1021/jacs.7b05151
Rina Mogaki, Kou Okuro,* Takuzo Aida*
J. Am. Chem. Soc. 2017, 139, 10072–10078. DOI: 10.1021/jacs.7b05151
Boronic Acid–Appended Molecular Glues for ATP-Responsive Activity Modulation of Enzymes
Kou Okuro,* Mizuki Sasaki, Takuzo Aida*
J. Am. Chem. Soc. 2016, 138, 5527–5530. DOI: 10.1021/jacs.6b0266
Kou Okuro,* Mizuki Sasaki, Takuzo Aida*
J. Am. Chem. Soc. 2016, 138, 5527–5530. DOI: 10.1021/jacs.6b0266
Photoinduced Bioorthogonal 1,3-Dipolar Polycycloaddition Promoted by Oxyanionic Substrates for Spatiotemporal Operation of Molecular Glues
Junichi Hatano, Kou Okuro,* Takuzo Aida*
Angew. Chem., Int. Ed. 2016, 55, 193–198. DOI: 10.1002/anie.20150798
Junichi Hatano, Kou Okuro,* Takuzo Aida*
Angew. Chem., Int. Ed. 2016, 55, 193–198. DOI: 10.1002/anie.20150798
Reductively Cleavable Nanocaplets for siRNA Delivery by Template-Assisted Oxidative Polymerization
P. K. Hashim, Kou Okuro,* Shigekazu Sasaki, Yasutaka Hoashi, Takuzo Aida*
J. Am. Chem. Soc. 2015, 137, 15608–15611. DOI: 10.1021/jacs.5b0894
P. K. Hashim, Kou Okuro,* Shigekazu Sasaki, Yasutaka Hoashi, Takuzo Aida*
J. Am. Chem. Soc. 2015, 137, 15608–15611. DOI: 10.1021/jacs.5b0894
Molecular Glues for Manipulating Enzymes: Trypsin Inhibition by Benzamidine-conjugated Molecular Glues
Rina Mogaki, Kou Okuro,* Takuzo Aida*
Chem. Sci. 2015, 6, 2802–2805. DOI: 10.1039/C5SC00524
Rina Mogaki, Kou Okuro,* Takuzo Aida*
Chem. Sci. 2015, 6, 2802–2805. DOI: 10.1039/C5SC00524
Subnanoscale Hydrophobic Modulation of Salt Bridges in Aqueous Media
Shuo Chen, Yoshimitsu Itoh,* Takuya Masuda, Seishi Shimizu, Jun Zhao, Jing Ma, Shugo Nakamura, Kou Okuro, Hidenori Noguchi, Kouhei Uosaki, Takuzo Aida*
Science 2015, 348, 555–559. DOI: 10.1126/science.aaa2421
Shuo Chen, Yoshimitsu Itoh,* Takuya Masuda, Seishi Shimizu, Jun Zhao, Jing Ma, Shugo Nakamura, Kou Okuro, Hidenori Noguchi, Kouhei Uosaki, Takuzo Aida*
Science 2015, 348, 555–559. DOI: 10.1126/science.aaa2421
Structure and Shape Effects of Molecular Glue on Supramolecular Tubulin Assemblies
Matteo Garzoni, Kou Okuro, Noriyuki Ishii, Takuzo Aida, Giovanni M. Pavan*
ACS Nano 2014, 8, 904–914. DOI: 10.1021/nn405653
Matteo Garzoni, Kou Okuro, Noriyuki Ishii, Takuzo Aida, Giovanni M. Pavan*
ACS Nano 2014, 8, 904–914. DOI: 10.1021/nn405653
Photoclickable Dendritic Molecular Glue: Noncovalent-to-Covalent Photochemical Transformation of Protein Hybrids
Noriyuki Uchida, Kou Okuro,* Yamato Niitani, Xiao Ling, Takayuki Ariga, Michio Tomishige,* Takuzo Aida*
J. Am. Chem. Soc. 2013, 135, 4684–4687. DOI: 10.1021/ja401059
Noriyuki Uchida, Kou Okuro,* Yamato Niitani, Xiao Ling, Takayuki Ariga, Michio Tomishige,* Takuzo Aida*
J. Am. Chem. Soc. 2013, 135, 4684–4687. DOI: 10.1021/ja401059
Friction-Mediated Dynamic Disordering of Phospholipid Membrane by Mechanical Motions of Photoresponsive Molecular Glue: Activation of Ion Permeation
Yushi Suzuki, Kou Okuro,* Tadashi Takeuchi, Takuzo Aida*
J. Am. Chem. Soc. 2012, 134, 15273–15276. DOI: 10.1021/ja307442
Highlighted by C&EN
Yushi Suzuki, Kou Okuro,* Tadashi Takeuchi, Takuzo Aida*
J. Am. Chem. Soc. 2012, 134, 15273–15276. DOI: 10.1021/ja307442
Highlighted by C&EN
Adhesion Effects of a Guanidinium Ion Appended Dendritic “Molecular Glue” on the ATP-driven Sliding Motion of Actomyosin
Kou Okuro, Kazushi Kinbara,* Kuniaki Takeda, Yuichi Inoue, Akihiko Ishijima, Takuzo Aida*
Angew. Chem., Int. Ed. 2010, 49, 3030–3033. DOI: 10.1002/anie.200906139
Selected as "Hot Paper", Highlighted by Nature Chemistry
Kou Okuro, Kazushi Kinbara,* Kuniaki Takeda, Yuichi Inoue, Akihiko Ishijima, Takuzo Aida*
Angew. Chem., Int. Ed. 2010, 49, 3030–3033. DOI: 10.1002/anie.200906139
Selected as "Hot Paper", Highlighted by Nature Chemistry
High-water-content Mouldable Hydrogels by Mixing Clay and a Dendritic Molecular Binder
Qigang Wang, Justin L. Mynar,* Masaru Yoshida, Eunji Lee, Myongsoo Lee, Kou Okuro, Kazushi Kinbara, Takuzo Aida*
Nature 2010, 463, 339–343. DOI: 10.1038/nature08693
Highlighted by C&EN, New Scientists, and Nature Protocols
Qigang Wang, Justin L. Mynar,* Masaru Yoshida, Eunji Lee, Myongsoo Lee, Kou Okuro, Kazushi Kinbara, Takuzo Aida*
Nature 2010, 463, 339–343. DOI: 10.1038/nature08693
Highlighted by C&EN, New Scientists, and Nature Protocols
Image Analysis of 𝛼/𝛽-Tubulin Rings in Two-dimensional Crystalline Arrays of Periodic Mesoporous Nanostructures
Noriyuki Ishii,* Kou Okuro, Kazushi Kinbara, Takuzo Aida
J. Biochem. 2010, 147, 555–563. DOI: 10.1093/jb/mvp201
Noriyuki Ishii,* Kou Okuro, Kazushi Kinbara, Takuzo Aida
J. Biochem. 2010, 147, 555–563. DOI: 10.1093/jb/mvp201
Molecular Glues Carrying Multiple Guanidinium Ion Pendants via an Oligoether Spacer: Stabilization of Microtubules against Depolymerization
Kou Okuro, Kazushi Kinbara,* Kouhei Tsumoto, Noriyuki Ishii, Takuzo Aida*
J. Am. Chem. Soc. 2009, 131, 1626–1627. DOI: 10.1021/ja800491v
Kou Okuro, Kazushi Kinbara,* Kouhei Tsumoto, Noriyuki Ishii, Takuzo Aida*
J. Am. Chem. Soc. 2009, 131, 1626–1627. DOI: 10.1021/ja800491v
Substrate Specificity and Reaction Mechanism of Recombinant Styrene Oxide Isomerase from Pseudomonas putida S12
Kenji Miyamoto, Kou Okuro, Hiromichi Ohta*
Tetrahedron Lett. 2007, 48, 3255–3257. DOI: 10.1016/j.tetlet.2007.03.016
Kenji Miyamoto, Kou Okuro, Hiromichi Ohta*
Tetrahedron Lett. 2007, 48, 3255–3257. DOI: 10.1016/j.tetlet.2007.03.016
