RESEARCH
Supramolecular Chemistry for Engineering of Biomolecular Interfaces
The surface of biomolecules plays essential roles in molecular recognition, binding, self-assembly, bio-distribution, and so forth. Engineering of biomolecular surfaces or "interfaces" is an important subject in the fields of chemical biology, biomaterial sciences, and medical sciences, for modulation and/or control of biomolecular functions. Our objective is to develop new molecular motifs for engineering of biomolecular interfaces based on supramolecular chemistry.
Guanidinium-based "Molecular Glues"
As a "universal" molecular tool for engineering biomolecular interfaces, we have developed "molecular glues" bearing multiple guanidinium ion pendants. Molecular glues can tightly adhere to the surface of biomolecules via multivalent salt-bridges with oxyanions. By means of molecular glues, we are trying to build functional biomolecular assemblies (project 1) and manipulate biomolecular functions (project 2). We are also developing a new soft materials consisting molecular glues and their derivatives (project 3).
BUILDConstruction of Biomolecular Assembly |
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Tubular Protein Assemblies
JACS 2009 Motor Protein Conjugates ACIE 2010, JACS 2013 Ring-shaped Protein Assemblies J. Biochem. 2010, ACS Nano 2014 Protein/siRNA Conjugates JACS 2019 |
MANIPULATEManipulation of Biomolecular Functions |
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Membrane Ion Permeation
JACS 2012 Control of Protein Functions Chem. Sci. 2015, JACS 2016, JACS 2017, JACS 2019, JACS 2020 Intracellular Drug Delivery JACS 2015, JACS 2018, Chem. Lett. 2018 |
