RESEARCH
Supramolecular Chemistry for Engineering of Biomolecular Interfaces
The surface of biomolecules plays essential roles in molecular recognition, binding, self-assembly, bio-distribution, and so forth. Engineering of biomolecular surfaces or "interfaces" is an important subject in the fields of chemical biology, biomaterial sciences, and medical sciences, for modulation and/or control of biomolecular functions. Our objective is to develop new molecular motifs for engineering of biomolecular interfaces based on supramolecular chemistry.
Guanidinium-based "Molecular Glues"
As a "universal" molecular tool for engineering biomolecular interfaces, we have developed "molecular glues" bearing multiple guanidinium ion pendants. Molecular glues can tightly adhere to the surface of biomolecules via multivalent salt-bridges with oxyanions. By means of molecular glues, we are trying to build functional biomolecular assemblies (project 1) and manipulate biomolecular functions (project 2). We are also developing a new soft materials consisting molecular glues and their derivatives (project 3).
BUILDConstruction of Biomolecular Assembly |
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Motor Protein Conjugates
JACS 2009, ACIE 2010, JACS 2013 Ring-shaped Protein Assemblies J. Biochem. 2010, ACS Nano 2014 Protein/siRNA Conjugates JACS 2019 Protein/Porous Material Conjugates ACIE 2021 |
MANIPULATEManipulation of Biomolecular Functions |
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Membrane Ion Permeation
JACS 2012 Control of Protein Functions Chem. Sci. 2015, JACS 2016, JACS 2017, JACS 2019, JACS 2020, JACS 2024 Intracellular Drug Delivery JACS 2015, JACS 2018, Chem. Lett. 2018 |
